Water and Salt Depletion

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Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite.

Water deprivation-induced thirst is explained by the double-depletion hypothesis, which predicts that dehydration of the two major body fluid compartments, the extracellular and intracellular compartments, activates signals that combine centrally to induce water intake. However, sodium appetite is also elicited by water deprivation. In this brief review, we stress the importance of the water-de...

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Increased cellular activity in rat insular cortex after water and salt ingestion induced by fluid depletion.

Insular cortex (IC) receives inputs from multiple sensory systems, including taste, and from receptors that monitor body electrolyte and fluid balance and blood pressure. This work analyzed metabolic activity of IC cells after water and sodium ingestion induced by sodium depletion. Rats were injected with the diuretic furosemide (10 mg/kg body wt), followed 5 min later by injections of the angi...

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Water and Salt Excretion

Jrntravenous salt-loading tests were performed in 20 hypertensive and 31 normotensive subjects. During the following 5 half-hour collection periods both water and salt excretion by the hypertensive subjects was higher than by the normotensive ones. The diuretic response was much more prolonged and more pronounced than the saluretic response and appears to be a primary response to the salt load,...

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ADH levels during salt depletion in dogs.

Two groups of trained dogs were subjected to sodium chloride depletion and plasma ADH concentration, renin activity, plasma sodium, plasma osmolality, blood volume, hematocrit and body weight were measured. I n one group of animals, sodium depletion was created by restricting intake to 5 mEq/24 h. Despite a statistically significant decrease in body wcight and blood volume and a corresponding i...

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Sodium depletion enhances salt palatability in rats.

Sterotyped fixed action patterns (FAPs) are elicited in rats by oral infusions of taste solutions. These taste-elicited FAPs can be classified as either ingestive or aversive. They reflect the palatability of the taste and can be modified by learning and by the physiological state of the animal. These studies demonstrated that when the physiological state of the rat is altered by sodium depleti...

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ژورنال

عنوان ژورنال: BMJ

سال: 1947

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.1.4508.781